Spatiotemporal AI-based modeling of gene regulation and variant effects in the developing human brain using Seal

Nature Neuroscience, Published online: 15 October 2026; doi:10.1038/s41593-026-02470-2

Seal is an artificial intelligence framework that predicts the effects of regulatory variants in 802 brain cell states, revealing spatiotemporal gene regulation and pinpointing cell types and developmental stages associated with neuropsychiatric conditions.