Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption in multiple sclerosis

Nature Neuroscience, Published online: 15 October 2026; doi:10.1038/s41593-026-02461-3

This study identifies ependymal dysfunction as a mechanism linking inflammatory cerebrospinal fluid to increased ventricular permeability and periventricular pathology in multiple sclerosis.