CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration

Nature Neuroscience, Published online: 30 September 2026; doi:10.1038/s41593-026-02423-9

Faini et al. develop CLOK, a method that labels neurons across a spectrum of colors according to when they were born, allowing successive generations of brain cells to be tracked as they take shape in living zebrafish.