Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach–avoidance decision-making

Nature Neuroscience, Published online: 15 September 2026; doi:10.1038/s41593-026-02444-4

Intracranial recordings reveal oppositely tuned activity in the medial and lateral regions of the human orbitofrontal cortex during approach–avoidance decisions: the medial orbital sulcus activates just before approach, whereas lateral orbitofrontal cortex activity decreases before approach.