SORDINO: silent, sensitive, specific and artifact-resistant fMRI in awake, behaving mice

Nature Neuroscience, Published online: 09 September 2026; doi:10.1038/s41593-026-02424-8

The authors develop SORDINO, a silent, sensitive and distortion-free fMRI method. They benchmark the technique against conventional approaches, reveal its functional contrast mechanisms and use it to perform brain-wide imaging of skilled motor behavior and social interaction in mice.