Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration

Nature Neuroscience, Published online: 03 September 2026; doi:10.1038/s41593-026-02427-5

The authors identify peripheral dendritic cell priming of T cells as a key driver of brain inflammation and neurodegeneration in a mouse model of tauopathy, providing new insights into immune mechanisms contributing to tau-dependent neurodegeneration.