Glutamate concentration tunes AMPA receptor function through conductance-state occupancy

Nature Neuroscience, Published online: 02 September 2026; doi:10.1038/s41593-026-02414-w

This study shows that glutamate concentration at synapses can dynamically reshape how synaptic AMPA receptors pass current and calcium. This reveals a rapid way that synapses tune communication in the brain.