Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development

Nature Neuroscience, Published online: 11 August 2026; doi:10.1038/s41593-026-02400-2

Using cerebroids, a 3D ex vivo model of the human fetal brain, the authors show that IL-17A, a mediator of maternal immune activation linked to neurodevelopmental disorders, disrupts early human cortical development through NF-κB signaling.