Focal astrocyte loss reveals nuclear translocation during lesion repopulation

Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02354-5

Herwerth et al. demonstrate that, after focal astrocyte loss in the adult brain, perilesional astrocytes undergo extensive remodeling, proliferation and nuclear translocation to repopulate the depleted tissue without forming a glial scar.