Replay of procedural memory is independent of the hippocampus

Nature Neuroscience, Published online: 23 July 2026; doi:10.1038/s41593-026-02362-5

Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error outcomes and predicted next-day motor performance improvements.