Striatal control of amygdalar acetylcholine release during salience-associated processing

Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02353-6

Amygdalar acetylcholine signals dynamically represent salience. Chen et al. show that striatal D1 and D2 neurons oppositely control these signals via basal forebrain cholinergic pathways to shape salience-associated learning.