Nature Neuroscience, Published online: 24 June 2026; doi:10.1038/s41593-026-02368-z
Brain aneurysms are a major cause of stroke worldwide, yet the cellular mechanisms that drive vessel instability remain poorly defined. A combined single-cell and spatial transcriptomic atlas of aneurysm tissue shows previously unrecognized interplay between scarring-associated fibroblasts and osteoclast-like macrophages that is associated with aneurysm formation and rupture.