Single-cell multi-omic atlas and morphogen screening informs midbrain and hindbrain organoid engineering

Nature Neuroscience, Published online: 03 June 2026; doi:10.1038/s41593-026-02316-x

By combining single-cell sequencing and morphogen screening, researchers map how signaling cues shape cell identity in mid-hindbrain organoids and identify conditions that generate novel posterior brain neuron types.