Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation

Nature Neuroscience, Published online: 30 April 2026; doi:10.1038/s41593-026-02263-7

The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-CoA from other sources being used for myelination.