White matter pathways mediating dorsolateral prefrontal TMS therapy for depression

Nature Neuroscience, Published online: 14 April 2026; doi:10.1038/s41593-026-02248-6

Seguin et al. show that the efficacy of transcranial magnetic stimulation for depression depends on how stimulation spreads through the brain’s wiring. Patients with shorter communication pathways between stimulated sites and mood-related regions had better clinical outcomes.