Neuropeptide Y co-opts neuronal ensembles for memory lability and stability

Nature Neuroscience, Published online: 31 March 2026; doi:10.1038/s41593-026-02235-x

This study from Wei-Guang Li, Tian-Le Xu and colleagues shows that neuropeptide Y released by specific hippocampal inhibitory neurons can switch fear memories into extinction memories by acting on two distinct receptor-defined neuron populations.