Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

Nature Neuroscience, Published online: 19 March 2026; doi:10.1038/s41593-026-02208-0

Single-nucleus epigenomic maps of the adult human brain and spinal cord reveal that adult oligodendroglia retain developmental chromatin patterns, suggesting a molecular memory that may shape repair processes and cancer vulnerability.