Distinct endocannabinoids specifically signal to astrocytes or neurons in the adult mouse hippocampus

Nature Neuroscience, Published online: 30 December 2025; doi:10.1038/s41593-025-02148-1

Distinct endocannabinoids signal to either astrocytes or neurons, evoking contrasting regulation of synaptic function. This works reveals the high degree of complexity of neuronal and astrocytic signaling in brain function.