A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging

Nature Neuroscience, Published online: 23 October 2025; doi:10.1038/s41593-025-02067-1

Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogramming of neurodegeneration-related pathways.