Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypes

Nature Neuroscience, Published online: 19 October 2026; doi:10.1038/s41593-026-02488-6

Molina et al. show in chronically stressed mice that neuronal and transcriptional adaptations in the habenula coincide with the onset of depressive phenotype, guiding temporally defined antidepressant interventions.