Investigating molecular and hemodynamic effects of LSD in the human brain

Nature Neuroscience, Published online: 12 October 2026; doi:10.1038/s41593-026-02462-2

Using simultaneous PET–MRI, McCulloch, Larsen and colleagues quantify LSD’s dose–occupancy relationship at the serotonin 2A receptor and reveal hemodynamic effects of LSD that contrast with those of psilocybin.