Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data

Nature Neuroscience, Published online: 08 October 2026; doi:10.1038/s41593-026-02472-0

Hou et al. show a drug target compendium supported by human genetic and real-world patient data for Alzheimer’s disease and validate epoxide hydrolase 2 as a causal Alzheimer’s disease target using CRISPR interference and gene editing experiments in human models.