Two parallel neural ectoderm progenitors contribute to the developing brain

Nature Neuroscience, Published online: 18 September 2026; doi:10.1038/s41593-026-02433-7

This study shows that the brain arises from two distinct progenitors: one forms the forebrain and midbrain, whereas the other generates the hindbrain. These insights enable the generation of human hindbrain motor neurons from pluripotent stem cells.