Nature Neuroscience, Published online: 09 September 2026; doi:10.1038/s41593-026-02401-1
Mapping brain-wide networks in behaving animals remains a formidable challenge. MacKinnon and colleagues introduce SORDINO-fMRI, a silent, motion-resistant framework that captures global dynamics during complex behaviors in mice while enabling artifact-free simultaneous network-level recordings with cellular or chemical validation. The method promises to open new opportunities in preclinical imaging and systems neuroscience.