Bone marrow myelopoiesis dysfunction in Alzheimer’s disease limits monocyte homing to the brain and drives disease progression

Nature Neuroscience, Published online: 08 September 2026; doi:10.1038/s41593-026-02417-7

Alzheimer’s disease progression involves reduced bone marrow production of myeloid cells due to type I interferon signaling, which hampers the homing of protective immune cells to the affected brain. In a mouse model, inhibiting this pathway restored immune cell recruitment and halted disease progression.