Roles of autophagy in brain homeostasis and disease

Nature Neuroscience, Published online: 24 August 2026; doi:10.1038/s41593-026-02426-6

Autophagy, a quality-control pathway for protein and organelle degradation, is indispensable to CNS cells, with impairments in autophagy linking it to a spectrum of disorders—from neurodegenerative to psychiatric diseases.