Cortical thickness changes precede high levels of amyloid by at least 7 years

Nature Neuroscience, Published online: 19 August 2026; doi:10.1038/s41593-026-02363-4

Longitudinal MRI reveals that the cortex becomes relatively thicker years before amyloid positivity is detected on PET, providing insight into the earliest brain changes and potential consequences of amyloid accumulation in Alzheimer’s disease.