A suite of engineered mice for interrogating psychedelic drug actions

Nature Neuroscience, Published online: 06 August 2026; doi:10.1038/s41593-026-02375-0

Chiu et al. have developed engineered HTR2A mouse lines enabling in vivo mapping, targeting and modulation of receptor-expressing neurons and validated their utility across biochemical, electrophysiological and behavioral studies of psychedelic mechanisms.