Norepinephrine and dopamine sensor crosstalk depends on local innervation density

Nature Neuroscience, Published online: 05 August 2026; doi:10.1038/s41593-026-02379-w

This study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and loss-of-function controls are required to interpret sensor signals.