A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes

Nature Neuroscience, Published online: 04 August 2026; doi:10.1038/s41593-026-02367-0

Klimmt, Cardoso Gonçalves et al. developed a reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and enabling the study of Alzheimer’s disease-relevant perturbations and drug responses.