Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease

Nature Neuroscience, Published online: 29 July 2026; doi:10.1038/s41593-026-02390-1

Researchers identify mitochondrial plaques, a previously unrecognized and highly acidic mitochondria-based pathological structure in Alzheimer’s disease, and demonstrate that they result from the dual pathological processes of mitochondrial accumulation and impaired clearance.