Adolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal–prefrontal synchrony

Nature Neuroscience, Published online: 20 July 2026; doi:10.1038/s41593-026-02369-y

Yu, Zhang et al. show that repeated exposure to the psychedelic drug 25C-NBOMe in adolescent rats, but not in adult rats, reduces willingness to engaged in food resource competition in adulthood, due to reduced theta synchrony between ventral hippocampus and orbitofrontal cortex.