Microglial TDP-43 mediates myelin refinement and represses Tyrobp cryptic exon inclusion in mice

Nature Neuroscience, Published online: 08 July 2026; doi:10.1038/s41593-026-02348-3

Compagnion et al. show that TDP-43 loss in microglia causes myelin defects, oligodendrocyte precursor cell imbalance and motor deficits in mice. They identify TDP-43 as a regulator of the TREM2-DAP12 signaling, through the control of Tyrobp mis-splicing.