The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence

Nature Neuroscience, Published online: 26 June 2026; doi:10.1038/s41593-026-02320-1

Mitochondrial proteotoxic stress rewires methionine and lipid metabolism in human microglia, driving cellular senescence and disrupting neuronal–glial communication, revealing a mechanism linking mitochondrial dysfunction to brain aging and neurodegeneration.