A fatty acid amide activates myeloid cells and improves neurovascular outcomes in retinal degeneration

Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02341-w

Erucamide, a fatty acid amide reduced in degenerating retinas, activates myeloid cells via TMEM19 to release neurotrophic and angiogenic factors, rescuing photoreceptors and vasculature in mouse models of retinal degeneration.