Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks

Nature Neuroscience, Published online: 01 June 2026; doi:10.1038/s41593-026-02301-4

In a nonhuman primate model, Fujimoto et al. show that deep brain stimulation promotes white matter remodeling and reorganizes brain-wide functional networks, detailing a mechanism through which this neuromodulation therapy may treat depression.