Foamy microglia link oxylipins to disease progression in multiple sclerosis

Nature Neuroscience, Published online: 21 May 2026; doi:10.1038/s41593-026-02302-3

Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and disease severity, highlighting potential therapeutic targets.