Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo

Nature Neuroscience, Published online: 24 April 2026; doi:10.1038/s41593-026-02247-7

By studying 23 neurodevelopmental disorder genes across model systems and brain cell types, the authors uncovered shared downstream effects that converge on synaptic biology, epigenetic regulation and mitochondrial function.