Early dopamine disruption in the entorhinal cortex of a knock-in model of Alzheimer’s disease

Nature Neuroscience, Published online: 23 April 2026; doi:10.1038/s41593-026-02260-w

The authors reveal entorhinal cortex dopaminergic and behavioral dysfunction in Alzheimer’s model mice, suggesting the possibility that entorhinal dopamine loss may contribute to aspects of Alzheimer’s disease.