Amyloid-β-driven glymphatic dysfunction in Alzheimer’s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol

Nature Neuroscience, Published online: 15 April 2026; doi:10.1038/s41593-026-02261-9

This study uncovers how amyloid-β boosts astrocyte calcium activity, increasing cholesterol and disrupting brain waste clearance in an Alzheimer’s disease mouse model. Targeting astrocyte calcium or cholesterol restores clearance and improves cognition.