Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia

Nature Neuroscience, Published online: 18 March 2026; doi:10.1038/s41593-026-02237-9

Zhou, Ho and colleagues show that, in mice, a schizophrenia-associated mutation impairs belief updating by weakening mediodorsal (MD) thalamus activity. Boosting this activity restored flexible decision-making, suggesting MD thalamus as a potential therapeutic target.