Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice

Nature Neuroscience, Published online: 26 February 2026; doi:10.1038/s41593-025-02199-4

Alzheimer’s disease alters brain structure broadly, but its regional impact is poorly mapped. Here, the authors show that App and Psen1 mutations in mice cause volume changes across 231 regions, which are associated with individual differences in behavior.