Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos

Nature Neuroscience, Published online: 17 February 2026; doi:10.1038/s41593-026-02201-7

Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective and reduces disease-associated paralysis.