Base barrier cells provide compartmentalization of choroid plexus, brain and CSF

Nature Neuroscience, Published online: 12 February 2026; doi:10.1038/s41593-025-02188-7

Verhaege et al. identify a conserved fibroblast barrier population at the base of the choroid plexus that compartmentalizes brain–CSF interfaces and is disrupted by inflammation, revealing a new site of central nervous system immune entry and barrier regulation.