TDP-43 loss induces cryptic polyadenylation in ALS/FTD

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02050-w

The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.