TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes

Nature Neuroscience, Published online: 21 October 2025; doi:10.1038/s41593-025-02049-3

Zeng et al. show that TDP-43, known for repressing cryptic exon usage in frontotemporal dementia/amyotrophic lateral sclerosis, also controls alternative polyadenylation, impacting expression of disease-linked genes (SFPQ, NEFL and TMEM106B).