Neurocardio Circuits in Stress & Adaptation
"We are committed to advancing research in neurocardiorespiratory regulation, specifically exploring how hypoxia influences brainstem circuits and their impact on cardiovascular and respiratory control."
Recent Publications
Orexin 1 receptors in the paraventricular nucleus of the hypothalamus (PVN) facilitate the peripheral chemoreflex
Ben Musa, R., Li, D.-P., Kline, D. D., Hasser, E. M., & Cummings, K. J. (2024). Physiology, 39(S1), 850. American […]
A serotonin-deficient rat model of neurogenic hypertension: Influence of sex and sympathetic vascular tone
Spinieli, R. L., Cornelius-Green, J., & Cummings, K. J. (2022). Journal of Neurophysiology, 128(5), 1199-1206.
The effect of orexin on the hypoxic ventilatory response of female rats is greatest in the active phase during diestrus
Ben Musa, R., Cornelius-Green, J., Hasser, E. M., & Cummings, K. J. (2023). Journal of Applied Physiology, 134(3), 638-648.
Orexin facilitates the hypoxic ventilatory response via the activation of corticotropin-releasing hormone neurons that project to the nucleus of the solitary tract
Ben Musa, R., Cornelius-Green, J., Hasser, E., Kline, D., & Cummings, K. (2023). Physiology, 38(S1), 5733602.
Orexin Facilitates the Peripheral Chemoreflex via Corticotropin-Releasing Hormone Neurons Projecting to the Nucleus of the Solitary
Ben Musa, R., Cornelius-Green, J., Zhang, H., Li, D.-P., Kline, D. D., Hasser, E. M., & Cummings, K. J. (2024). […]
Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses
Ruyle, B. C., Lima-Silveira, L., Martinez, D., Cummings, K. J., Heesch, C. M., Kline, D. D., & Hasser, E. M. […]
Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS) …
Cummings, K. J., Leiter, J. C., Trachtenberg, F. L., Okaty, B. W., Darnall, R. A., Haas, E. A., Harper, R. […]
About Us

The Cummings Lab focuses on understanding how the brainstem integrates signals from central autonomic pathways to regulate critical functions such as blood pressure and heart rate.
Primarily located in the medulla oblongata, these neural centers dynamically adapt to physiological challenges, maintaining homeostasis during stress or environmental changes, including hypoxia. Our research explores how hypoxia disrupts these pathways, leading to maladaptive cardiovascular and respiratory responses.
Using advanced techniques like in vivo rodent models, electrophysiology, neuroimaging, and nerve recordings, we aim to uncover deeper insights into disorders such as Sudden Infant Death Syndrome (SIDS) and cardiorespiratory conditions in both infants and adults.
Dr. Kevin J. Cummings leads a multidisciplinary team of postdoctoral researchers and collaborators in neuroscience, electrophysiology, and autonomic regulation.
We employ a variety of advanced research techniques, including:
Optogenetics & Chemogenetics,
Electrophysiology, Fluorescence & Photometry, and in Vivo Monitoring of blood pressure, heart rate, and respiratory function in awake, behaving rodents.
Science News
For some, childhood adversity can promote resilience to anxiety disorders
Research has shown that young people who face adversity such as traumatic or stressful events during brain development are 40% […]
Repurposed ALS drug becomes imaging probe to help diagnose neurodegeneration
Positron emission tomography (PET) is a nuclear imaging technique used to diagnose conditions such as cancer. An innovative advance from […]
Uncovering dementia’s environmental triggers
A new study from the University of Georgia College of Public Health focuses on the powerful role our surroundings play […]
Brain mapping unlocks key Alzheimer’s insights
Researchers from The University of Texas at Arlington and the University of California-San Francisco have used a new brain-mapping technique […]
How the brain decides when to stick at it, give up or try something new
To survive, animals must continually decide whether to persevere with their current goal, switch to a new one or disengage […]
Collaborate with Us:
We welcome partnerships with other researchers, institutions, and clinical professionals. Whether you're interested in sharing expertise, contributing to ongoing projects, or exploring new ideas, we encourage collaboration to expand the scope of our research. We invite proposals for joint studies, grant applications, and academic exchanges. Our multidisciplinary team thrives on diverse input from experts in various scientific and clinical fields.
Current opportunities:
We are constantly seeking passionate and driven researchers to join our dynamic team. We provide exciting opportunities for graduate students, postdoctoral researchers, and lab assistants to collaborate on cutting-edge projects and contribute to groundbreaking discoveries. Join us to advance your career in a supportive and innovative research environment.
